These proven supplements have a history of effectiveness and safety for depression vs prescription drugs. Learn how they work and get recommended dosages.
Table of Contents
In the past few decades, the use of prescription antidepressants has increased dramatically. (1)
But these drugs are not right for many people.
Children, teens, pregnant women, and the elderly are not good candidates.
Prescription antidepressants work only about half the time, can have unacceptable side effects, and do not mix with many medications.
While the safety and effectiveness of antidepressant drugs are in question, there is an array of supplements that are both safe and effective for treating depression.
The Top Herbal Supplements for Depression
Herbs have been used traditionally to treat depression in every culture.
Apparently, depression is not just a modern problem.
Here’s a look at some of the best herbal supplements — those with a history of safe use that have also been scientifically proven to be effective.
Caution: If you currently take a prescription antidepressant, talk to your doctor before making any changes to your medication.
1. Arctic Root (Rhodiola rosea)
Arctic root is found mainly in cold Arctic regions of Europe, Asia, and North America. (2)
It’s been used since the time of the ancient Greeks to boost overall physical and mental vitality.
This herb is a top-rated adaptogen, a natural substance that increases your resilience to physical and emotional stress. (3)
It works by increasing the activity of brain chemicals that impact your mood such as serotonin, norepinephrine, and dopamine. (4)
Arctic root has been shown to reduce depression symptoms faster than antidepressant medications. (5)
It’s particularly useful for depression accompanied by anxiety and fatigue, depression caused by seasonal affective disorder (SAD), or when you need results quickly.
2. Ashwagandha (Withania somnifera)
Ashwagandha is one of the most important herbs in the Indian Ayurvedic healing discipline.
Like Arctic root, it’s an adaptogenic herb.
What makes ashwagandha a standout is its ability to reduce levels of the stress hormone cortisol. (6)
Ashwagandha is an excellent choice if you have depression along with stress, anxiety, and insomnia. (7)
3. Chamomile (Matricaria recutita or Chamaemelum nobile)
Chamomile is a cheery, daisy-like plant that’s an excellent multipurpose relaxing herb.
It can be served as a tea, taken in capsule or tincture form, or used as a relaxing essential oil.
It’s so safe that it was traditionally used to treat childhood ailments such as diarrhea, colic, croup, and fevers. (8)
Chamomile is particularly beneficial for those dealing with both depression and anxiety. (9)
There are two main species of chamomile used medicinally — German or wild chamomile (Matricaria recutita) and Roman or English chamomile (Chamaemelum nobile).
German chamomile is more commonly used, but both offer similar health benefits.
4. Curcumin (Curcuma longa)
Curcumin is the main active ingredient in the Indian spice turmeric (Curcuma longa) which is renowned for its anti-inflammatory and brain-boosting properties.
Curcumin works by increasing levels of two feel-good neurotransmitters, serotonin and dopamine. (10)
Studies have shown it to be as effective for depression as the popular antidepressant Prozac. (11)
Both turmeric and curcumin supplements can be taken for depression indefinitely.
5. Ginkgo (Ginkgo biloba)
Ginkgo biloba is an ancient Chinese herb that’s now one of the most popular herbal supplements in the world.
" A healthy brain is the first line of defense against depression and other mood disorders.
Ginkgo is another adaptogenic herb that reduces stress and anxiety by lowering levels of cortisol. (20)
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6. Saffron (Crocus sativus)
Saffron is one of the rarest and most expensive culinary spices.
It comes from the tiny red stigmas of the purple saffron crocus and must be harvested by hand.
A little-known benefit of saffron is that it’s one of the most promising herbal supplements for depression.
The exact mechanism isn’t fully understood yet, but saffron seems to work by acting on serotonin metabolism. (24)
One other notable benefit of saffron is that it reduces hunger and the urge to snack.
Saffron is also helpful for anxiety, stress, OCD, and PMS.
While generally considered safe, the only caveat is that high doses of saffron should be avoided by women who are pregnant since it can stimulate contractions. (25)
When buying any supplement, quality matters, but with saffron, quality matters more than usual.
Since it’s expensive, saffron fraud is rampant.
Look for a supplement that’s manufactured by a reputable company and contains a standardized extract of Crocus sativus.
Historical note: Saffron fraud is nothing new. People have been faking saffron since the time of the ancient Greeks. (26)
The Top Vitamin Supplements for Depression
Vitamin deficiency is not the first thing you think of when considering the underlying causes of depression.
Doctors and psychiatrists rarely recommend vitamins for depression either.
But clearly, your brain can’t operate at its peak when essential nutrients are missing.
A healthy brain is the first line of defense against depression and other mood disorders.
Some vitamins are necessary for the formation of mood-boosting neurotransmitters, while others provide energy to brain cells or protect them from damage.
Here’s a look at the most important vitamins for depression and their recommended dosages.
1. Vitamin B6 (Pyridoxine): A Serotonin Cofactor
Serotonin is the main brain chemical responsible for making you feel happy, relaxed, and confident.
It also plays an important role in sleep, sex drive, and digestive health.
The most prevalent theory of depression is that it’s caused by a lack of serotonin.
This is why the most commonly prescribed antidepressants are selective serotonin reuptake inhibitors (SSRIs) which work by increasing serotonin levels in the brain.
Normally, serotonin is created in the brain and body from tryptophan, an amino acid commonly found in meat, poultry, fish, and dairy products.
Tryptophan provides the basic building blocks used to synthesize serotonin, but certain cofactors — vitamin B6, folic acid, vitamin C, iron (Fe), magnesium (Mg), calcium (Ca), and zinc (Zn) — must be present for this reaction to take place.
Notice that vitamin B6 is used twice in this two-step process.
Vitamin B6 is also needed to make dopamine, another neurotransmitter associated with depression. (27)
Additionally, low levels of vitamin B6 contribute to chronic inflammation, an underlying cause of many health conditions, including mood disorders and neurological diseases. (30)
Vitamin B6 Supplement Dosages
The RDA (Recommended Dietary Allowance) for vitamin B6 is 1.3 mg daily for most adults.
Pregnant women need more (1.9 mg) as do seniors (1.5 mg for women, 1.7 mg for men). (34)
If you take supplements like 5-HTP or tryptophan for depression, look for one that includes B6 in the supplement’s formulation.
Without this vitamin, these ingredients can’t do their intended job of increasing serotonin.
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2. Vitamin B9 (Folate): Enhances Antidepressant Drugs
Vitamin B9 is usually called folate or folic acid.
People with major depression consistently have low blood levels of folate. (35)
Folic acid acts as an antidepressant by affecting serotonin receptors in the brain. (36)
The potential benefits of taking folic acid for depression are so great that one study concluded that all patients with depression should be treated with folic acid. (39)
Also, folate protects the brain from environmental neurotoxins and from the buildup of the toxic brain plaques that are a factor in Alzheimer’s. (40)
Vitamin B9 Supplement Dosages
The terms folate and folic acid are used interchangeably but are not exactly the same.
Folate occurs naturally in foods, while folic acid is a synthetic form found in supplements and fortified foods.
The recommended dietary allowance of folic acid is 400 mcg for most adults and 600 mcg for pregnant women. (41)
Some people have a mutation in the MTHFR gene that makes it hard to process vitamin B9.
If you know or suspect that you have this gene, look for folate supplements that use the methylated folate form rather than the usual folic acid form of B9.
3. Vitamin B12 (Cobalamin): For Nerve and Brain Health
Vitamin B12 is found in everyday foods, yet vitamin B12 deficiency is surprisingly common, possibly affecting 40% of all adults. (42)
It’s critical for a healthy nervous system and for the formation of serotonin. (43)
Vitamin B12 deficiency can be quite serious and should not be taken lightly.
If left untreated, it leads to irreversible nerve damage and can be life-threatening.
If you suspect you are deficient in this important nutrient, get your vitamin B12 blood level checked and supplement accordingly.
Vitamin B12 Supplement Dosages
You’ll find several forms of B12 in supplements — cyanocobalamin, methylcobalamin, and hydroxocobalamin.
There seems to be little difference in absorption or bioavailability for most people. (50)
The RDA for vitamin B12 is 2.4 mcg/day, but if you look at supplement labels, you’ll find that most supplements contain much more. (51)
Manufacturers provide megadose levels of B12 since only about 2% of it is actually absorbed. (52)
There are no known adverse effects from taking these large doses.
Interestingly, for those with compromised digestive systems, supplemental B12 is absorbed more efficiently than B12 from food where it’s bound to protein. (53)
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4. Vitamin C (Ascorbic Acid): A Natural Antidepressant
Vitamin C isn’t just for colds; it’s also a proven stress reducer and antidepressant.
It slows the release of the stress hormone cortisol which increases susceptibility to depression. (54)
People with low vitamin C levels are often depressed and fatigued. (55)
Study participants who took vitamin C reported feeling happier, often within as little as one week. (56)
Vitamin C is yet another serotonin cofactor that acts as a natural antidepressant.
Severe vitamin C deficiency causes mice to act depressed by reducing serotonin and dopamine levels in their brains. (57)
One study found that vitamin C enhanced the effectiveness of the antidepressant Prozac in children who were depressed. (58)
Vitamin C is required to produce norepinephrine, a chemical that acts as both a stress hormone and a neurotransmitter. (59)
Vitamin C is also a potent antioxidant.
Antioxidants protect the brain by reducing free radical damage and inflammation, a potential cause of depression. (62)
Vitamin C Supplement Dosages
The RDA for vitamin C is 75-90 mg/day, but most experts believe this amount to be ridiculously low.
Most studies use much higher dosages.
One study on depression had participants taking 3,000 mg per day. (63)
You can safely take more, but doses over 2,000 mg per day can cause digestive upset in some people.
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5. Vitamin D: The Sunshine Vitamin
Vitamin D has profound effects on the brain during all stages of life, from infancy through senior years. (66)
A major meta analysis of studies that included over 31,000 participants linked low levels of vitamin D to depression. (70)
It’s not fully understood how vitamin D works, but a prevailing theory is that it boosts levels of serotonin, dopamine, and norepinephrine — all feel-good brain chemicals necessary for a positive mood. (71)
Vitamin D may alleviate depression by being anti-inflammatory.
One study found that suicidal patients had low vitamin D levels and high concentrations of compounds that promote inflammation. (72)
One systematic review of studies concluded that vitamin D compares favorably to fluoxetine (Prozac) as an antidepressant. (73)
This is not surprising since vitamin D regulates the conversion of tryptophan into serotonin. (74)
Additionally, vitamin D has been shown to enhance the effectiveness of Prozac. (75)
Vitamin D Deficiency Is Epidemic
Vitamin D deficiency is disturbingly common.
It’s been called an “ignored epidemic” that affects over 1 billion people worldwide. (76)
Vitamin D is synthesized when your skin is exposed to sunlight.
But most of us spend too much time indoors or covered with sunscreen to manufacture appreciable amounts, especially during the winter months.
Low levels of vitamin D, rather than fewer hours of daylight, may be the underlying cause of seasonal affective disorder, a type of depression that affects millions during the winter. (77)
By far the best way to get vitamin D is from exposure to the sun.
But if you live north of the 37th parallel (37 degrees latitude) in the northern hemisphere or south of that in the southern hemisphere, the sun’s rays are too weak to trigger vitamin D production most of the year.
It’s only when the UV index is greater than 3 that the needed UVB wavelengths are present in sufficient amounts to produce vitamin D. (78)
You can find your current local UV index at Weather.com or Accuweather.com, or by using a reputable UV index app.
Food Is Not a Good Way to Get Sufficient Vitamin D
It’s very difficult to get all the vitamin D you need from food.
There are only a few foods that contain vitamin D3, the best-utilized form.
The best food sources are salmon, mackerel, tuna, and sardines. (79)
Small amounts are found in beef liver, cheese, and egg yolks.
Some foods contain vitamin D2, such as mushrooms, fortified milk or orange juice, but the body does not utilize the D2 form well.
This makes vitamin D supplementation the only viable option for most people unless you live in and spend time outside in a location that’s warm and sunny year-round.
Vitamin D Supplement Dosages
Vitamin D dosages were previously labeled in IU (International Units).
But the US Food and Drug Administration now requires that food and supplement labels show the amount in micrograms (mcg) as well. (80)
Note that 1 mcg is equivalent to 40 IU.
The current RDA for vitamin D is 15 mcg (600 IU) per day, but this amount is hotly contested. (81)
The only way you can know your vitamin D status for sure is to take a 25-hydroxy vitamin D test. (84)
You can see your doctor or order a vitamin D test kit here.
If you have depression, this is a worthwhile investment in your mental health.
Vitamin D is so important for depression that your doctor should ideally run this test before prescribing you an antidepressant.
And since vitamin D is fat-soluble and gets stored in your body’s fat cells and liver, it is possible to accumulate too much of it — another good reason to get your level checked.
Interestingly, excessive sun exposure does not result in vitamin D toxicity since your body has a way of regulating vitamin D production.
When choosing a supplement, be sure to buy from a reputable company you can trust.
A study on 55 brands of vitamin D supplements found that the contents diverged wildly, containing as little as 9% and as much as 146% of what was listed on the label. (85)
6. Multivitamin Supplements (really!) for Depression
Modern life is full of vitamin drains.
Alcohol, caffeine, smoking, stress, sugar, toxins, prescription medications, and malabsorption issues are among the many factors that increase your brain’s demand for vitamins.
And some people have inherently greater requirements for certain nutrients than the average person.
Don’t underestimate the power of a good multivitamin supplement for helping mood disorders.
There are occasions when a single-nutrient supplement is warranted.
But starting with a reputable multivitamin and mineral supplement is more convenient and economical, and does a better job of covering all your basic needs.
Taking a multivitamin supplement as nutritional insurance can help you be healthier, happier, and may even help you live longer. (90)
Two Depression Supplements to Use With Caution
Just because a supplement is natural doesn’t necessarily mean that it’s without risks.
Here are two supplements often taken for depression that don’t meet the criteria of being both safe and effective.
St. John’s Wort (Hypericum perforatum)
St. John’s wort is one of the most popular herbal supplements for depression, but it’s not one we recommend.
It has a deserved reputation for causing side effects and negative interactions.
Ironically, reported side effects of St. John’s wort are very similar to those of SSRI antidepressants — anxiety, panic attacks, dizziness, nausea, and spikes in blood pressure. (91)
Compared with other herbal supplements, St. John’s wort is more likely to have negative drug interactions.
It has known interactions with hundreds of medications! (92)
When taken with antidepressants, it can cause serotonin syndrome, a potentially fatal condition.
It should not be taken by women who are taking birth control pills since it can render them less effective. (93)
5-HTP is another popular supplement for depression that we recommend only as a last resort.
A meta-analysis of over 100 studies concluded that there is insufficient evidence that 5-HTP helps depression. (94)
Importantly, 5-HTP is not recommended for long-term use since it increases serotonin at the expense of other equally important neurotransmitters. (95)
And finally, it is not safe to mix 5-HTP with antidepressants or numerous natural remedies, including St. John’s wort. (96)
Supplements for Depression: Take the Next Step
Depression is a widespread problem, but antidepressant medications don’t work for many people and are not safe for large demographics of the population.
But there are natural supplements that are both safe and effective for depression.
Some supplements have antidepressant properties of their own, while others work by addressing underlying causes of depression such as nutritional deficiency, brain inflammation, or neurotransmitter imbalance.
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