The Impressive Brain Benefits of Curcumin Supplements

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Last updated October 10, 2023.
Edited and medically reviewed by Patrick Alban, DC. Written by Deane Alban.

Studies show that curcumin, a bioactive compound in turmeric, can help depression, anxiety, brain aging, and neurodegenerative diseases.

Curcumin is the main bioactive compound in the Indian spice turmeric.

It’s responsible for turmeric’s brilliant gold color and most of its impressive health benefits.

Curcumin is most commonly taken to fight the pain and inflammation of arthritis, but it’s also a standout brain enhancer and protector.

Curcumin supplements can help lift mood, control stress and anxiety, and protect the brain against aging and neurodegenerative diseases.

Here’s why this remarkable compound is nutritional gold for brain and mental health.

The Mental Health Benefits of Curcumin Supplements

Curcumin exhibits a wide array of healthful properties.

It’s naturally anti-inflammatory, antioxidant, antiviral, antibacterial, antifungal, and anti-cancer.

Over 300 compounds have been found in turmeric and while curcumin isn’t the only beneficial compound, it is the most promising and widely studied. 

Here are the notable mental health benefits of curcumin that have been discovered so far:

1. Curcumin Is a Natural Antidepressant

Curcumin shows great potential as a natural antidepressant.

In fact, it’s been found to be as effective for depression as the popular selective serotonin reuptake inhibitor Prozac (fluoxetine). 

" Unlike many other drugs and supplements, curcumin can safely be combined with antidepressant medications and actually enhances their effectiveness.

This is great news for the millions who have tried antidepressants without success, or for those who have experienced unacceptable side effects. 

Curcumin is believed to work by increasing two key neurotransmitters linked to depression, serotonin and dopamine. 


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In one study, three groups of patients with depression were given either curcumin, Prozac, or a combination of both. 

Curcumin supplements were found to be as effective as Prozac, and patients who took both curcumin and Prozac experienced the greatest relief from their depression. 

Another way curcumin impacts depression is by reducing brain inflammation

There is now compelling evidence that depression may be one of many diseases caused by chronic inflammation.

If you experience depression, even major depressive disorder, there is no downside to taking curcumin supplements

Curcumin is safe for most people to take indefinitely.

And unlike many other drugs and supplements, curcumin can safely be combined with antidepressant medications and actually enhances their effectiveness. 

Curcumin can also be safely combined with other natural remedies for depression, such as St. John’s wort and SAM-e.

2. Curcumin Protects Against Brain Aging

Curcumin nourishes and protects the brain in a variety of ways.

It’s a potent antioxidant that readily crosses the blood-brain barrier to protect brain cells against free radical damage.

Curcumin can improve memory and concentration by increasing blood flow to the brain

Impressively, one study found that taking curcumin supplements improved blood flow as well as physical exercise

Another study found that one dose of curcumin significantly improved attention and working memory in healthy seniors within an hour

Curcumin raises the level of brain-derived neurotrophic factor (BDNF), a protein that stimulates the creation of new brain cells. 

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Additionally, it can boost neuroplasticity, the brain’s ability to change and grow. 

New research shows that curcumin increases the bioavailability of DHA (docosahexaenoic acid), an omega-3 essential fatty acid that’s a fundamental building block of the brain.

DHA deficiency is implicated in mental health and neurological disorders such as depression and anxiety. 

Curcumin enhances DHA synthesis and elevates its level in the brain. 

Finally, and perhaps most importantly, curcumin is powerfully anti-inflammatory.

Chronic inflammation has been called a silent killer that contributes to eight of the top ten leading causes of death. 

Chronic inflammation of the brain shuts down energy production in brain cells, causing mental fatigue and slowing down the firing of neurons.

This, in turn, can lead to anxiety, depression, brain fog, ADHD, and memory loss, as well as serious neurological conditions such as stroke and Alzheimer’s. 

3. Curcumin Shows Potential for Treating Alzheimer’s

One of the most potentially exciting uses for curcumin is in helping to prevent Alzheimer’s.

Populations that consume turmeric as a regular part of their diet have low rates of this dreaded disease.

A senior in the US, for example, has a 4 times greater risk of developing Alzheimer’s than a senior in India, due to the latter’s use of turmeric in cooking. 

Preliminary studies show that curcumin breaks up the plaques found in the brains of Alzheimer’s patients. 

It also reduces inflammation, oxidative stress, and metal toxicity — all believed to play a role in Alzheimer’s.

However, it’s widely agreed that more research is needed, especially clinical trials. 


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Curcumin also shows promise for treating Parkinson’s disease by preventing the clumping of a protein found in the first stages of this disease. 

It is being studied as a potential treatment by the Michael J. Fox Foundation for Parkinson’s Research. 

4. Curcumin Supplements Relieve Stress and Anxiety

There hasn’t been a lot of research done on curcumin for stress and anxiety, but here’s what a few studies show.

Curcumin, when taken alone or with the herbal antidepressant saffron (Crocus sativus), effectively minimizes both anxiety and depression symptoms in people with major depressive disorder.

When curcumin is taken with the herb fenugreek, it reduces stress, anxiety, and fatigue, while increasing the quality of life in people suffering from extreme occupational stress. 

Curcumin can alleviate the anxiety experienced by women with premenstrual syndrome (PMS).

The severity of PMS-related emotional, behavioral, and physical symptoms has been shown to be significantly reduced with curcumin supplementation. 

There are also a few relevant animal studies to consider.

When curcumin is given to rats under stress, it helps to normalize cortisol balance, adrenal gland function, BDNF levels, and behavior. 

Dietary deficiency of DHA is linked to several mental health disorders, including anxiety.

Curcumin boosts DHA levels in the brain and reduces symptoms of anxiety. 

Obsessive-compulsive disorder (OCD) is a common anxiety disorder characterized by compulsive behavior.

Curcumin supplementation has resulted in significant improvement in the compulsiveness and associated memory loss of OCD

Curcumin vs Turmeric: What’s the Difference? Which Is Better?

Understanding the difference between curcumin and turmeric supplements can be confusing and a lot of the information found online doesn’t help. 

Many websites, even authoritative medical sites, incorrectly use the terms turmeric and curcumin interchangeably.

Here’s what you need to know about curcumin and turmeric.

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What Is Turmeric?

Turmeric is a root that comes from a tropical plant (Curcuma longa).

Most commonly, it is dried and sold as a spice or sometimes as a tea.

However, it’s becoming more common to find fresh turmeric root at some health food stores or grocery stores. 

Turmeric is also sold as a supplement in the form of capsules, gummies, or liquid extracts.

What Is Curcumin?

Curcumin, on the other hand, is the main bioactive ingredient in turmeric.

It is extracted from turmeric and sold as a supplement.

Curcumin is not unique to turmeric; it is also found in ginger, another spice with a long history of medicinal use.

Proven Benefits of Curcumin vs Turmeric

Many websites make unrealistic claims about turmeric supplements.

A few natural health websites boldly state that turmeric has been proven beneficial for over 600 ailments.

However, the vast majority of research studies have been done using isolated curcumin, not turmeric.

At the very least, it’s not known whether turmeric offers the same health benefits as curcumin since research has yet to be done.

There are two practical reasons why more studies have been done on curcumin than turmeric.

It’s much easier to study a compound like curcumin which can be isolated and standardized.

And, of course, there is little monetary incentive to research a spice that’s already found in millions of kitchens worldwide and cannot be patented and turned into a profitable supplement.

Potential Benefits of Turmeric vs Curcumin

Not everyone is convinced that curcumin is superior to turmeric.

Johns Hopkins University professor of oncology Saraswati Sukumar, PhD, contends that cooking with turmeric provides more benefits than taking curcumin supplements which are less bioavailable and generally less effective. 

Many experts believe that whole plant supplements are usually more beneficial than supplements created from only part of the plant.

By way of analogy, think of curcumin as a single musical note and turmeric as a symphony.

The theory is that all the organic chemicals in turmeric work together for greater effect. 

For example, another promising compound in turmeric is turmerone.

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Studies show that turmerone stimulates the production of new neurons, making it useful in treating degenerative brain diseases, such as Alzheimer’s, Parkinson’s, traumatic brain injury, and stroke. 

By singling out curcumin, you’d be missing out on this important benefit.

Andrew Weil, MD, a world-renowned pioneer in the field of integrative medicine, differentiates between curcumin and turmeric in this way:

“… until proven otherwise in head to head studies, whole plants are usually a better choice than isolates. On the other hand, curcumin appears to have a more rapid and dramatic effect, and may be the better choice as a therapeutic (rather than a preventative) preparation.” 

The takeaway here is that it may be helpful to use a curcumin supplement for its short-term therapeutic effects and to add turmeric to your diet as a long-term prevention strategy.

Turmeric vs Curcumin Safety

Another consideration is the safety of curcumin compared to turmeric.

Turmeric consumed in food is extremely safe, but like most supplements, curcumin has potential side effects and should not be mixed with some medications, which we’ll discuss shortly.

This means that not everyone can safely take a curcumin supplement.

A surprising way that turmeric powder can be hazardous is as a source of lead

This is true whether you buy turmeric as a spice or as a supplement.

Brands that have been found to be adulterated come from India or Bangladesh.

Disturbingly, some experts suspect that turmeric is being intentionally adulterated with lead to enhance its weight and/or color. 

The Curcumin vs Turmeric Dilemma Solved

“Curcumin vs turmeric” does not have to be an “either/or” situation.

There’s no reason you can’t take a curcumin supplement and make turmeric a regular part of your diet.

In fact, there’s evidence that turmeric and a curcumin supplement work together, enhancing each other’s effects

Why Your Curcumin Supplement Should Be Enhanced

Curcumin makes up only about 3% of most turmeric powders and is very poorly absorbed

Up to 85% of the curcumin in an unenhanced supplement passes through the intestines unused

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For these reasons, it makes sense to take a supplement that has been enhanced to increase its absorption.

Scientists are working on high-tech ways to make curcumin more bioavailable by using nanoparticles or by combining it with phosphatidylserine, a potent brain booster in its own right. 

But it turns out that one way to get greater curcumin benefits was discovered thousands of years ago.

In traditional Southwest Asian cooking, turmeric is used with black pepper.

Both are key ingredients in curry powder, a staple of the cuisines of India, Pakistan, and Afghanistan.

The use of black pepper greatly increases the bioavailability of curcumin.

It’s now known that the compound piperine that is found in black pepper is responsible — it increases curcumin absorption 20-fold

If your curcumin supplement is not enhanced, you can greatly increase its enhancement by simply taking it with a meal

One study on curcumin bioavailability found that it readily enters the brain even when the only “enhancement” is to take it with food. 

This makes sense considering that the presence of oil greatly enhances the absorption of fat-soluble curcumin as well. 

When shopping for a curcumin supplement, you’ll almost certainly come across those that contain patented and/or trademarked ingredients such as BioPerine®, Longvida®, Theracurmin®, Meriva®, or BCM-95®.

These ingredients claim to increase the absorption and/or bioavailability of unenhanced curcumin by a factor of:

Our advice is to pick a curcumin supplement that’s been enhanced, but not to stress too much about these numbers since there is no way to know the actual amount entering your brain anyway.

Curcumin Supplement Dosage

Getting an authoritative answer about the amount of curcumin to take is hard.

There is no Recommended Dietary Allowance (RDA) for curcumin, nor is there universal agreement on how much curcumin constitutes a therapeutic dose. 

And frustratingly, many websites confuse turmeric dosages with curcumin dosages.

Suggested dosages for curcumin range from 500 mg to 1,000 mg, provided the supplement manufacturer has taken steps to enhance bioavailability. 

Most curcumin supplements are sold in 500 mg capsules.

You rarely have to worry about taking too much curcumin.

(A few exceptions follow shortly.)

Researchers have found curcumin to be safe at doses as high as 12 grams per day

Curcumin Supplement Side Effects and Interactions

Since curcumin is a naturally occurring compound, you might assume it’s completely safe.

But curcumin supplements have a surprising number of possible side effects, interactions, and warnings.

While clearly turmeric and curcumin are not the same thing, their side effects and interactions are confusingly treated the same on sites like and

According to these sources, you should not take either turmeric or curcumin supplements if you have these conditions or issues.

However, there is no mention that you should stop consuming turmeric as part of a healthy diet. 


Curcumin stimulates the uterus and increases the risk of a miscarriage.

You should also avoid it if you are trying to conceive.

Note that its safety while breastfeeding has not been established.

Hormone Sensitivity

Curcumin acts like a phytoestrogen

So it should be avoided if you have reproductive cancer, endometriosis, or uterine fibroids.


If you currently have gallstones or gallbladder disease, it’s best to avoid curcumin. 

It can stimulate bile flow and gallbladder contractions. 

Scheduled Surgery

If you are scheduled for surgery, it’s recommended that you stop taking curcumin or turmeric supplements 2 weeks prior.

Since these supplements have blood-thinning properties, taking them could slow blood clotting or cause extra bleeding during and after surgery.

Blood Thinners

If you take a prescription blood thinner, be aware that curcumin increases the risk of bruising and bleeding.

Digestive Conditions

Turmeric and curcumin are a mixed bag for the gastrointestinal tract.

By stimulating the gall bladder to produce bile, turmeric can reduce the gas and bloating of indigestion.

It may help keep ulcerative colitis in remission.

However, by increasing stomach acid it can lead to gastritis and make stomach ulcers worse. 

Taking curcumin with food minimizes these negative effects. 

Note that turmeric and curcumin can interfere with the actions of medications that reduce stomach acid, such as Zantac, Tagamet, and Nexium. 


If you have diabetes, talk to your doctor before taking curcumin.

It can lower blood sugar and when used in conjunction with anti-diabetic drugs can increase the risk of hypoglycemia (low blood sugar) or change the need for medication. 

Iron Deficiency

If you have low iron levels, skip curcumin and turmeric supplements.

Curcumin binds with iron, inhibiting its absorption. 

Drug Interactions

According to, more than 130 drugs interact adversely with turmeric and curcumin supplements, including seemingly innocuous over-the-counter remedies like aspirin and acetaminophen.

You can find a complete list of interactions here.

Lastly, the piperine added to some curcumin supplements can also amplify the effects of a number of drugs.

If you take any medication for high blood pressure, asthma, allergies, or seizures, talk to your doctor or pharmacist before mixing it with a curcumin supplement that contains piperine or BioPerine. 

A safer choice would be to take a curcumin supplement enhanced with either Theracurmin (which uses nanoparticles) or Meriva (which uses phospholipids) instead.

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