Best Supplements to Reduce Cortisol (extensive guide)

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Last updated February 1, 2023.
Edited and medically reviewed by Patrick Alban, DC. Written by Deane Alban.

These supplements are proven to reduce cortisol, a stress hormone that, in excess, is often the cause of physical and mental health problems.

Cortisol is our primary stress hormone.

It’s useful during emergencies, but chronic stress can create an outpouring of cortisol all day long — and that’s a problem.

Excess cortisol leads to a host of physical health problems and also puts us at greater risk for anxiety, depression, memory loss, and cognitive decline. 

The majority of research on cortisol and supplements that affect it has been carried out on animals.

And a surprising number of clinical trials measure how various substances affect the cortisol level of athletes in extreme circumstances, such as running an ultramarathon. 

If you think that that kind of research isn’t applicable to the average person, you’d be right.

Let’s take a look at the best cortisol supplements — those shown to reduce cortisol in average humans under ordinary circumstances.

The Best Herbal Supplements to Reduce Cortisol

There are many herbal remedies known to alleviate stress by reducing cortisol.

The following have both long histories of use for stress and the scientific evidence to support that they reduce cortisol in humans.


Ashwagandha (Withania somnifera) is a traditional Ayurvedic herb used mainly to treat anxiety.

It belongs to a select group of herbs referred to as adaptogens — natural remedies that counter the physical and mental effects of stress.

" Ashwagandha excels at stress reduction and decreases cortisol significantly more than many other supplements.

Adaptogens are neither stimulating nor sedating, but bring the body into a state of balance known as homeostasis.

Numerous studies confirm that ashwagandha is a powerful cortisol buster.

It significantly reduces cortisol levels in chronically stressed humans by up to 30%. 


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Arctic Root

Arctic root (Rhodiola rosea) is another adaptogenic herb used in traditional Chinese medicine to increase vigor and stamina.

It reduces cortisol and increases resilience to stress, but is slightly energizing rather than sedating.

This makes it a good choice if you are both stressed and fatigued.

Arctic root can also significantly reduce depression symptoms, sometimes by as much as 50%. 

It works not just by reducing cortisol, but also by increasing dopamine, serotonin, and norepinephrine — brain chemicals that have an appreciable impact on mood. 

One clinical trial showed that Arctic root significantly lowered the cortisol response brought on by chronic stress. 

Study participants experienced less burnout and improved mental performance.

Arctic root goes by many common names including rose root, rosenroot, and golden root.

So when choosing a supplement, be sure to look for one that contains genuine Rhodiola rosea.


Bacopa (Bacopa monnieri) is another traditional Ayurvedic herb that’s considered both an adaptogen and a nootropic — a substance that safely enhances mental performance.

It has been traditionally used to treat anxiety, insomnia, fatigue, depression, and disorders of the digestive system, heart, and lungs.

When healthy adults were given KeenMind®, a patented standardized bacopa extract, they experienced decreases in cortisol and improvements in mood and the ability to perform mental tasks.

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Ginkgo (Ginkgo biloba) is one of the most popular brain supplements, which has recently been found to not live up to its reputation as a memory enhancer

Dozens of studies on thousands of people have reached the same conclusion: that ginkgo does very little to improve memory or help prevent mental decline in healthy adults. 

However, ginkgo does reduce blood pressure and symptoms of stress by lowering cortisol levels


Cordyceps is a fungus used in traditional Chinese medicine mainly to increase stamina and promote longevity.

Cordyceps is a genus of over 750 species, but two, Cordyceps sinensis and cordyceps militaris, are commonly sold as supplements. 

You won’t find cordyceps growing in the woods though; this fungus is a parasite that grows in caterpillars!

Cordyceps has been found to improve physical performance and, as an adaptogen, is believed to normalize cortisol levels.

Other Supplements That Lower Cortisol

Not all supplements that reduce cortisol in humans are herbs.

This next group of supplements is a mixed bag that includes fats, a compound found only in tea, and a certain kind of fiber.

Fish Oil

Fish oil is the most popular supplemental source of omega-3 essential fatty acids.

Fish oil supplements have positive effects on brain functions of all kinds — mood, memory, cognition, and general mental well-being.

One of the ways it works is by blunting the stress response and effectively reducing cortisol levels. 

This makes it beneficial for those with psychiatric disorders such as depression, borderline personality disorder, ADHD, and schizophrenia. 

One omega-3 found in fish oil, DHA (docosahexaenoic acid), is an essential structural component of brain cells.

People low in DHA have measurably smaller brains that age faster than normal. 


It’s almost impossible to live a lifestyle that provides all the nutrients needed for good brain health and performance. The reason? All of us confront multiple nutrient thieves — stress, poor diet, insomnia, pharmaceuticals, pollution, and more — that steal nutrients that the brain needs to thrive.

Taking quality nutritional supplements:
  • Provides the building blocks to create new brain cells and brain chemicals
  • Helps increase resilience to stress to avoid mental burnout
  • Supplies the brain with the fuel it needs for mental energy

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Phosphatidylserine is a fat that naturally occurs in high concentrations in the brain and nervous system.

It reduces the effects of both physical and mental stress by keeping cortisol levels down. 

Phosphatidylserine is an outstanding brain supplement in its own right.

In fact, it is the only supplement to receive a qualified stamp of approval from the US Food and Drug Administration for cognitive decline and dementia. 

Numerous studies have measured the effects of phosphatidylserine on the stress experienced by athletes such as runners, cyclists, golfers, and even Olympians.

During these studies, it was discovered that phosphatidylserine decreased cortisol, increased physical performance, and reduced post-exercise muscle soreness and recovery time.  


L-theanine is an amino acid found almost exclusively in black, green, white, and oolong teas.

It is widely regarded for inducing a state of “calm attentiveness.”

Cortisol reduction may be one of the ways it achieves this.

When study participants were given a drink that contained 200 mg of l-theanine, they reported feeling less stressed afterwards and their cortisol response was substantially blunted for up to three hours. 

It would be hard to consume this much l-theanine from tea which generally has 25 mg per cup, but you can easily get a 200 mg dose with an l-theanine supplement.


Prebiotics are foods that contain insoluble fibers that “good” intestinal bacteria feed on.

Interestingly, the ingestion of prebiotic fibers suppresses the stress response and reduces cortisol in healthy adults. 

While you can buy prebiotic fiber supplements, it’s usually not necessary since there are plenty of common foods that contain prebiotic fiber.

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Among the best prebiotic fiber-filled foods are: 

  • apples
  • bananas
  • chocolate
  • garlic
  • oats
  • onions
  • tomatoes
  • wheat

So the next time you are stressed out and tempted to grab unhealthy comfort food, reach for a snack that contains one or more of these top prebiotic foods instead.

Supplements That May Reduce Cortisol

This next group includes supplements that may reduce cortisol.

And what does that mean?

There are many supplements that purportedly decrease cortisol, but their supporting evidence relies exclusively on animal studies or their results in human trials have been inconclusive.

Supplements that have been found to reduce cortisol, but only in animal studies, include:

This doesn’t mean that these supplements won’t have the same effects in humans, but it does mean that their effectiveness in humans has not yet been clinically proven.

Next, let’s take a look at some supplements that have been studied in humans, but with mixed results. 


In the case of ginseng (Panax ginseng), numerous studies have found that it reduces cortisol in mice, rats, and rabbits

But when a clinical trial (i.e., a human study) was conducted, the study participants did not experience a change in cortisol levels. 


The evidence is similarly mixed for schisandra (Schisandra chinensis), a berry used in traditional Chinese medicine.

Most studies on the effects of schisandra on cortisol involve animals. 

The one study performed on humans found that it decreased cortisol levels, but only in trained athletes after heavy physical exertion. 

Unless you are an athlete, there’s currently little evidence that schisandra will reduce your cortisol levels.


While magnesium definitely is a relaxing, anti-anxiety mineral, the evidence for magnesium lowering cortisol levels is inconsistent.

Various studies have concluded that magnesium decreases cortisol (after exercise), that magnesium has no effect on cortisol levels in sedentary subjects, and that magnesium substantially increases cortisol (after exercise). 

And some research suggests that magnesium modulates the release of cortisol, dialing it up and down as needed. 


Curcumin is the main bioactive compound in the spice turmeric.

It is a top-notch brain supplement that’s beneficial for anxiety, depression, and neurodegenerative diseases.

It helps to normalize cortisol balance, adrenal gland function, and brain-derived neurotrophic factor (BDNF) levels, but, so far, only in lab animals. 


Numerous vitamins show some cortisol-busting potential.

Vitamins C, B1, B2, and B3 (niacin) have been found to reduce cortisol, but only after prolonged physical exercise. 


One study found that taking a zinc supplement dramatically inhibits the release of cortisol

But another study found the change in cortisol levels to be statistically insignificant. 

One Supplement That Increases Cortisol

When most people are looking for a cortisol supplement, what they really want is an anti-cortisol supplement — one that decreases cortisol.

However, there is a cortisol supplement that increases cortisol if that’s something you seek to do.

People with Addison’s disease, also known as adrenal insufficiency, benefit from licorice root supplements which contain glycyrrhetic acid, a compound that increases cortisol. 

Licorice root (Glycyrrhiza glabra) is a multipurpose herb used in both traditional Chinese and Ayurvedic healing, most commonly for digestive disorders.

You may be familiar with it as the flavoring used in natural licorice candies.

Which Cortisol Supplements to Try First

With a number of cortisol-reducing supplements to choose from, you may be unsure which one or ones to try first.

Here are my recommendations in priority order.

#1. Satisfy Your Core Nutritional Needs First

Having a nutritional deficiency is a physical stressor, so it’s imperative that you meet your daily requirements of vitamins, minerals, and particularly, essential fatty acids.

Stress is a notorious nutrient drain and virtually everyone under stress could benefit from a high-quality multivitamin-mineral supplement and an omega-3 supplement in the form of fish oil or krill oil.

Most multivitamin supplements are relatively low in magnesium, so consider taking additional magnesium separately.

Magnesium is extremely important for combating stress and it’s estimated that 75% of us have an inadequate intake

#2. Try Ashwagandha or Phosphatidylserine

Next, I’d suggest starting with either the traditional Ayurvedic remedy ashwagandha or phosphatidylserine, depending on which symptoms of stress you’re experiencing.

Ashwagandha excels at stress reduction and decreases cortisol significantly more than many other supplements.

It’s a good choice if you have anxiety, insomnia, or depression caused by stress.

Phosphatidylserine is another proven cortisol reducer.

It’s also an excellent brain supplement that improves memory and protects against mental decline, while enhancing physical performance.

[This article contains only a quick summary of each cortisol supplement we’ve mentioned. Search our site to find in-depth articles on most of these supplements.]

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