15 Links Between Caffeine and Anxiety

➤ ContentOur original articles are based on high-quality, widely accepted, research-based information. Sources include government agencies, universities and colleges, scholarly journals, industry and professional associations, and other authoritative resources. Use the article's inline links to visit these sources. When theories and concepts do not have broad support within the scientific community, we present both sides of the issue. Information provided by BeBrainFit.com is for informational purposes only and does not constitute medical advice, diagnosis, or treatment. See our Terms of Use for details.
➤ ProductsBe Brain Fit is supported by you, our audience. We provide links to products that we think can help you achieve better brain and mental health. We earn revenue when you buy through our links, at no cost to you. See our Terms of Use for details.

Last updated January 10, 2024.
Edited and medically reviewed by Patrick Alban, DC. Written by Deane Alban.

Caffeine is a psychoactive drug that can cause or exacerbate anxiety and other stress-related signs and symptoms in many ways. Learn what you can do.

If you have an anxiety disorder, and you’re concerned that caffeine is making it worse, your suspicions may be right.

Caffeine is a central nervous system stimulant that can significantly contribute to anxiety. 

There’s evidence that quitting caffeine can be even more beneficial for anxiety than taking prescription anti-anxiety drugs!

Here are 15 ways that caffeine is linked to anxiety … and what you can do about it.

1. Caffeine Increases Stress Hormones

Most people who deal with anxiety would agree that they have too much stress in their lives — and caffeine adds to the burden.

Caffeine affects the body much like stress by increasing heart rate, blood pressure, and levels of stress hormones.

" Some psychiatrists recommend that routine psychiatric assessments should include examining caffeine consumption since removing caffeine can be more beneficial than prescribing anti-anxiety drugs.

Caffeine consumption can more than double the blood levels of the stress hormones cortisol and epinephrine

2. Caffeine Affects Neurotransmitter Balance

Caffeine achieves many of its effects by blocking the activity of adenosine, a neurotransmitter that makes you feel sleepy and tired.

By increasing the brain chemicals dopamine and acetylcholine, caffeine imparts feelings and results that we desire, such as increased motivation, mental function, and productivity. 

But for those with anxiety, there is a downside.

Caffeine also inhibits the calming neurotransmitter GABA (gamma-aminobutyric acid). 


I hear this question often. Here's my answer:

#1 Live a brain-healthy lifestyle first (Be Brain Fit tells you how).

#2 Give Mind Lab Pro a try.

This brain supplement meets all 12 of my requirements for a high-quality brain supplement, including effectiveness, safety, purity, and value. So it's easier for you to be mentally sharper, positive, and more productive.

Choosing the right brain supplement is all about quality. And, when you buy a 3-month supply, you get 1 extra month free. See why I recommend Mind Lab Pro.

Dr. Pat

GABA slows brain activity when necessary and has been called “nature’s Valium.”

It’s essential for feeling happy and relaxed, so it’s not surprising that low GABA levels are associated with anxiety and panic attacks.

Serotonin is the neurotransmitter most closely tied to happiness.

But there’s evidence that caffeine, which can cross the blood-brain barrier, decreases levels of serotonin in the brain. 

3. Caffeine Causes Insomnia

One of the most common side effects of both anxiety and caffeine consumption is insomnia.

In fact, caffeine-induced sleep disorder is a recognized psychiatric disorder. 

If anxious thoughts make you restless at night, caffeine can compound the problem.

Caffeine disrupts the normal sleep cycle, making it harder for restorative sleep to take place. 

Getting adequate high-quality sleep is one of the most important things you can do for brain health and mental well-being.

It’s during sleep that the brain washes away toxins and metabolic debris, repairs itself, consolidates memories, and creates new brain cells

Caffeine consumed even six hours before bedtime can significantly disrupt sleep, so you may find that you need to stop caffeine ingestion earlier than you thought. 

4. You May Have Caffeine Sensitivity

We all know people who can drink a pot of coffee after dinner and sleep like a rock.

If you have anxiety, you probably aren’t one of them.

The difference may be in your genes.

Scientists from Harvard School of Public Health have found several genes that directly influence how your body metabolizes caffeine. 

Download, listen, relax ... Experience the power of hypnosis. Hypnosis Downloads. Try it now.

You may be sensitive to caffeine because you take longer to metabolize it.

The average half-life of caffeine is 5-6 hours, but everyone is different and the time it can take to eliminate caffeine from the body varies widely.

It can take as little as two to as many as ten hours after ingestion to metabolize half of it

Related on Be Brain Fit —
The Effects of Caffeine on Depression

And there are other reasons you may be sensitive to caffeine.

Caffeine sensitivity increases with age, so you might not be able to drink caffeine like you used to. 

Men metabolize caffeine more slowly than most women, the exceptions being women who are pregnant or taking birth control pills

Caffeine sensitivity can be caused by an allergic reaction to caffeine, although true caffeine allergy is rare

More common is an allergy to mycotoxins, toxins produced by fungi and mold, that are found in coffee. 

You may be taking medications that increase the side effects of caffeine.

Drinking alcoholic beverages slows down caffeine breakdown.

So do some healthy foods such as broccoli and some herbal teas. 

An impaired ability to process caffeine is not unusual in people with liver disease, especially cirrhosis. 

5. Caffeine May Aggravate Hypoglycemia

Hypoglycemia occurs when your blood sugar level drops too low.

A low blood sugar attack can leave you feeling jittery, sweating, irritable, and confused, with a pounding heart — a lot like an anxiety attack.


It’s almost impossible to live a lifestyle that provides all the nutrients needed for good brain health and performance. The reason? All of us confront multiple nutrient thieves — stress, poor diet, insomnia, pharmaceuticals, pollution, and more — that steal nutrients that the brain needs to thrive.

Taking quality nutritional supplements:
  • Provides the building blocks to create new brain cells and brain chemicals
  • Helps increase resilience to stress to avoid mental burnout
  • Supplies the brain with the fuel it needs for mental energy

A foundational principle of mental health and cognitive performance is to supply the body with the best nutrition possible. And, when you buy a 3-month supply of any Performance Lab supplement, you get 1 extra month free. See why I recommend Performance Lab.

Dr. Pat

Caffeine stimulates the release of the stress hormones cortisol, epinephrine, and norepinephrine, causing blood sugar levels to drop

If you suspect that your low blood sugar is exacerbated by caffeine, try going without it and notice if you experience any improvement.

6. Medications Plus Caffeine Can Increase Anxiety

Caffeine is so much a part of our culture that it’s easy to forget that it’s a psychoactive drug and, consequently, doesn’t always mix well with other drugs.

Drugs.com currently lists more than 60 medications that should not be taken with caffeine.

Sometimes, caffeine enhances the effects of some drugs; it’s often added to over-the-counter painkillers to make them work better.

But other times, caffeine can undermine the effectiveness of a medication by affecting its absorption, metabolism, or excretion.

It can also increase the number of side effects as is the case with asthma medications, antidepressants, and some antibiotics. 

Anti-anxiety medications, sleeping pills, and lithium for bipolar disorder fall into this category.

Pharmacist Suzy Cohen, RPh, reveals some alarming interactions between caffeine and prescription drugs in her book Drug Muggers: Which Medications Are Robbing Your Body of Essential Nutrients — and Natural Ways to Restore Them.

She reports that caffeine can cause tremors, panic attacks, and insomnia when taken with antidepressants that are SSRIs (selective serotonin reuptake inhibitors).

Caffeine should be avoided when taking breathing medications that contain the stimulant xanthine.

When taken together, these drugs can cause anxiety as well as dangerous heart palpitations, shortness of breath, and arrhythmia.

When caffeine is used with ADHD medications like Adderall and Ritalin, it increases nervousness, irritability, insomnia, and heart rhythm abnormalities.

7. Added Caffeine Is an Unregulated, Synthetic Chemical

Many plants contain caffeine.

Coffee, teas (from the Camellia sinensis plant), cocoa, and yerba mate all contain caffeine naturally.

But the caffeine found in sodas, energy drinks, energy gel packs, and caffeine pills and powders is rarely extracted from tea leaves or coffee grounds; that would be prohibitively expensive.

The demand for added caffeine has far outstripped natural caffeine production since World War II.

Added caffeine is synthetically manufactured in pharmaceutical plants from chemical precursors like urea and chloroacetic acid.

Mind Lab Pro is the best nootropic supplement

It is usually made in China or sometimes in India or Germany.

Journalist and self-proclaimed caffeine addict Murray Carpenter, author of Caffeinated: How Our Daily Habit Helps, Hurts, and Hooks Us, traveled to China to check out the world’s largest caffeine plant while doing research for his book.

It was not the high-tech facility he imagined.

Here’s how he described the caffeine factory in his book:

… half the windows were smashed, and rags streamed out. Bags of stockpiled chemicals sat inside the broken first-floor windows. The place reeked — a chemical stench to make you gag — and a tall rusty tank leaked a tarry sludge.

He reveals that if you drink soda or energy drinks, you’ve almost certainly consumed caffeine produced there.

Lastly, don’t be impressed if you see the words “naturally caffeinated” on a product label.

It’s not unusual for manufacturers to ignore labeling requirements and use the synthetic version anyway. 

Natural and synthetic caffeine are technically identical, yet can be told apart by carbon dating

Synthetic caffeine registers as “older” since it’s sourced from fossil fuels.

Oddly, synthetic caffeine can exhibit another telltale sign — sometimes it glows

8. Too Much Caffeine Is Linked to Psychiatric Disorders

It’s been recognized for decades that the symptoms of too much caffeine are very similar to those of many psychiatric disorders.

Enough caffeine can even create symptoms of anxiety in a healthy person that are indistinguishable from those experienced by anxiety disorder sufferers.

Some psychiatrists recommend that routine psychiatric assessments should include examining caffeine consumption since removing caffeine can be more beneficial than prescribing anti-anxiety drugs.

Related on Be Brain Fit —
11 Benefits of Tapping for Anxiety Relief

Caffeine use has been linked to mental disorders of all kinds, including anxiety, panic, depression, and sleep and eating disorders.

Taking schizophrenic patients off caffeine has been found to reduce their anxiety, irritability, and hostility. 

Some experts are so convinced that caffeine is problematic that they’ve recommended that only decaffeinated beverages be available in psychiatric wards

Performance Lab MCT is the best mct oil supplement

9. Caffeine Causes at Least Four Recognized Mental Disorders

The Diagnostic and Statistical Manual of Mental Disorders (DSM) is the American Psychiatric Association’s standard guide of mental disorders.

The DSM currently recognizes four caffeine-related disorders: 

  • caffeine intoxication
  • caffeine-induced anxiety disorder
  • caffeine-induced sleep disorder
  • caffeine withdrawal disorder

The World Health Organization and many healthcare professionals recognize caffeine addiction as a clinical disorder.

For now, the preferred term is caffeine use disorder

It’s been included as a condition for further study in the latest version of the DSM.

10. It’s Easier Than Ever to Overdo Caffeine Consumption

There are more sources of caffeine than ever before.

You expect to find it in coffee, tea, chocolate, and cola soda, but it’s also hidden in prescription drugs, over-the-counter painkillers, non-cola drinks, vitamin waters, brain tonics, and even in vitamins and herbal supplements. 

Caffeine is commonly added to so-called brain supplements, often as part of a proprietary blend which means that the label doesn’t tell you how much caffeine the supplement contains.

The amount of caffeine in energy drinks can be deceiving since the serving sizes of some of these drinks are so small.

5-Hour Energy Shot contains a jaw-dropping 100 mg of caffeine per ounce.

Another problem is that labels aren’t always accurate.

In one incidence, 40,000 cases of Sunkist orange soda were found to contain 240 mg of caffeine per bottle, nearly six times the 41 mg listed on the label.  

Performance Lab Energy is the best stim free energy supplement

Caffeine’s effects are consistently underestimated.

According to the book Caffeinated, here’s what escalating amounts of caffeine can do to you:

  • 1/64 teaspoon will give you a subtle boost
  • 1/16 teaspoon (the amount in 12 oz of coffee) can lead to addiction
  • 1/4 teaspoon causes acute anxiety
  • 1 tablespoon is enough to kill an adult

It’s thought to be virtually impossible to drink yourself to death with naturally occurring caffeine.

But now, pure caffeine pills and powder can easily and inexpensively make caffeine overdose a reality.

Sadly, there have been numerous deaths caused by caffeine powder overdose

Tragically, there have recently been two deaths attributed to the consumption of Panera Bread’s “charged lemonade” which contained 390 mg of caffeine per 30-ounce serving.  

11. Caffeine Robs You of Essential Brain Nutrients

Caffeine causes nutrients to be excreted from your body, some of which are particularly important for your brain health and mood.

One of the nutrients that gets depleted is magnesium, a mineral that has profound effects on your mental wellness. 

Magnesium plays a critical role in a number of neurological and psychological disorders, including: 

Caffeine also robs you of the B vitamins which act as “anti-stress vitamins.”

Anxiety is a common sign of B vitamin deficiency.

Taking extra B vitamins can address imbalances of the brain chemicals GABA, serotonin, dopamine, and epinephrine that contribute to anxiety. 

12. Caffeine Restricts Blood Flow to the Brain

When you are anxious, blood flow to the brain is already reduced and caffeine can reduce it further.

Caffeine restricts blood flow to the brain by as much as 27%. 

Blood flow is the delivery system for getting nutrients of all kinds to your brain, including oxygen, water, glucose, vitamins, and minerals.

An interesting aside is that many people take brain supplements and nootropics such as ginkgo, citicoline, curcumin, and vinpocetine which work, in part, by increasing blood flow to the brain.

What they don’t realize is that the caffeine they drink essentially neutralizes this benefit!

13. Women Experience Hormone-Related Sensitivity to Caffeine

Caffeine’s effects vary depending on how quickly you process it.

If you are pregnant or taking birth control pills, it can take longer to process caffeine than usual, up to twice the usual half-life of four to five hours. 

This means that you’ll get double the side effects from any caffeine you consume.

Caffeine also increases symptoms of menopause, including anxiety, insomnia, hot flashes, bone loss (by leaching calcium), heart palpitations, and mood swings.

Likewise, caffeine can also worsen the anxiety, fatigue, and irritability experienced by women with premenstrual syndrome (PMS).

14. Caffeine Induces “Panic Attacks on Demand” for Scientific Research

It’s notoriously difficult to study panic attacks since study subjects don’t experience them on demand.

Or can they?

Caffeine so reliably induces panic attacks that it’s used for that purpose in studies.

By giving participants with social anxiety disorder 480 mg of caffeine, 61% of them experienced caffeine-induced panic attacks. 

Researchers have also used caffeine to induce auditory hallucinations in test subjects. 

15. Caffeine Withdrawal Causes Anxiety

If you have anxiety, caffeine gets you coming and going.

Not only does it make you feel anxious when you drink it, but it also makes you anxious when you quit drinking it.

As mentioned earlier, caffeine withdrawal is one of the four recognized caffeine-related mental disorders. 

Withdrawal symptoms include anxiety as well as brain fog, depression, irritability, fatigue, insomnia, muscle aches, and nausea.

This may make you reluctant to try quitting, but it’s still worth it since the worst of caffeine withdrawal usually lasts only a few days.

The Worst and Best Caffeinated Drinks If You Have Anxiety

Not all sources of caffeine are equally beneficial or detrimental.

Here’s a quick rundown of the worst and the best sources of caffeine if you have anxiety. 

The Worst Caffeinated Drinks for Anxiety

Soft drinks contain synthetic caffeine and loads of sugar and have no nutritive value.

Energy drinks are no better even though they may contain minute amounts of added herbs or vitamins.

The International Society of Sports Nutrition has concluded that any performance enhancement from energy drinks comes from caffeine and sugar, NOT from these added nutrients. 

The Best Caffeinated Drinks for Anxiety

Coffee, tea, and yerba mate are naturally caffeinated drinks that contain antioxidants, vitamins, minerals, amino acids, and phytonutrients that offer major benefits that can make you and your brain healthier.

If you’d like to continue to drink some caffeine to stay alert and productive, there’s no better drink than green tea.

It contains a modest amount of caffeine (25 mg per cup). 

It will help you stay simultaneously calm and focused due to two unique compounds, EGCG and l-theanine.

EGCG (epigallocatechin gallate) is a potent antioxidant that can improve your mood and make you more resilient to stress by moderating brainwave activity and increasing the calming neurotransmitter GABA

One study found EGCG to be as effective at relieving anxiety as the anti-anxiety medication benzodiazepine. 

L-theanine is a relaxing amino acid that causes an increase in alpha brainwave activity, putting you in a state similar to that experienced during meditation. 

The caffeine, EGCG, and theanine in green tea work together to induce a desirable state of calm alertness. 

Recommended: Upgrading brain health is key to making your brain work better.

Mind Lab Pro is the brain supplement I recommend because, by boosting your brain health, it can help you:

  • Improve your mental clarity and focus.
  • Boost your memory and your ability to learn.
  • Increase your capacity to think critically, solve problems, and make decisions.
See our MIND LAB PRO review.

Dr. Pat

P.S. Like what you've read on this page? Get more like this -- Sign up for our emails.