GABA Supplements for Stress and Anxiety (& which work best)

GABA is a major inhibitory neurotransmitter. A GABA deficiency can be a big factor contributing to stress and anxiety. Learn how to increase GABA naturally.

Low GABA is associated with numerous disorders with a stress component including anxiety disorders, depression, insomnia, migraines, and fibromyalgia.

A GABA deficiency is also linked to autism, schizophrenia, bipolar disorder, and epilepsy. (1)

While it is possible to have a genetic disorder of GABA metabolism, lifestyle is almost always the underlying cause of a GABA deficiency. (2)

Harvard Medical School researcher Datis Kharrazian, PhD, DHSc, states in his book Why Isn’t My Brain Working?that stress, poor diet, lack of sleep, too much caffeine, and gluten intolerance are common culprits.

GABA Supplements for Stress, Anxiety, and Insomnia

Anti-anxiety drugs (Valium, Xanax) and sleeping pills (Ambien, Lunesta) work by helping GABA bind to the appropriate receptors in the brain. (3)

Julia Ross, MA, is the author of The Mood Cure and a pioneer in the field of biochemical rebalancing.

She finds that “GABA acts like a sponge, soaking up excess adrenaline and other byproducts of stress.”

If you are looking to increase your GABA levels with supplements instead of drugs, you have two choices.

You can take a supplement that contains synthetic GABA.

There’s an ongoing controversy among the experts as to whether GABA supplements can work at all.

The scientific community generally concurs that synthesized GABA supplements should NOT work since GABA molecules are too large to cross the blood-brain barrier and enter the brain. (4)

This barrier acts as the brain’s gatekeeper to keep out foreign substances.

There are several theories that may explain why GABA supplements seem to work some of the time in spite of this.

A long-standing explanation is that GABA supplements work only for those who have a compromised, or leaky, blood-brain barrier.

But new theories are coming to light.

It’s suspected that certain areas of the brain allow small amounts of GABA to enter. (5, 6)

Another possibility is that GABA binds with receptors found in the peripheral nervous system, rather than those in the brain. (7, 8)

Taking a synthetic GABA supplement may or may not work for you.

The only way to know for sure is to give it a try.

GABA Supplements: Dosage, Side Effects, and Interactions

One additional concern about the use of synthetic GABA supplements is that little research has been done on them.

A standard dosage has yet to be determined, but most supplements come in 500-750 mg doses.

GABA supplements are generally considered safe, but common side effects include digestive upset, fatigue, muscle weakness, and shortness of breath. (9)

Most of them have a long history of safe and effective use for stress relief, anxiety, and insomnia.

These are the most effective GABA-boosting supplements:

Taurine — A Good Place to Start

As a GABA booster, taurine is an excellent place to start.

Taurine is an amino acid found in high concentrations in the brain where it acts much like a neurotransmitter by activating GABA receptors. (11)

Additionally, taurine encourages the formation and release of GABA. (12)

Magnesium — A Missing Mineral

Magnesium is an essential dietary mineral that is excellent for stress and anxiety.

Unfortunately, deficiency is common and it’s estimated 75% of us have subpar levels. (13)

Magnesium-depleted soils, stress, age, medications, and underlying health conditions all contribute to widespread magnesium deficiency. (14)

One way in which magnesium helps with stress relief is by binding to and stimulating GABA receptors in the brain. (15)

If you feel “tired but wired,” have chronic insomnia, or often have nocturnal leg cramps, magnesium supplementation may be the answer.

L-Theanine — Change Your Brainwaves

L-theanine is a uniquely relaxing amino acid found in black, white, green, and oolong teas. (16)

It increases the levels of GABA and serotonin and dopamine, two other important neurotransmitters. (17)

L-theanine is considered an adaptogen, a stress-relieving substance that makes you more resilient to life stressors. (18)

One of the interesting attributes of l-theanine is that it alters your brainwave state similarly to meditation.

The alpha brainwave state is associated with relaxation and the beta state with stress and anxiety.

GABA increases alpha waves and decreases beta waves — and so does l-theanine. (19, 20, 21)

Kava works in part by increasing GABA levels. (23)

It’s been found to be as effective for anxiety and generalized anxiety disorder (GAD) as the prescription anti-anxiety drugs Buspirone and Opipramol. (24)

It also shows promise for treating ADHD by providing cognitive enhancement and relaxation effects. (25)

You can take kava as a supplement or consume it the traditional way — as a tea.

Psychobiotics — Probiotics for the Brain

Probiotic supplements that provide mental health benefits are called psychobiotics.

One way psychobiotics enhance mental well-being is by creating neurotransmitters, including GABA. (26)

Research has found over two dozen strains of bacteria, mostly strains of Lactobacillus, that produce GABA. (27)

So far, Lactobacillus brevis has been found to be the best GABA synthesizer.

Other top GABA producers include Lactobacillus paracasei and Lactobacillus buchneri. (28)

Lactobacillus rhamnosus increases GABA levels and facilitates direct communication between the gut and the brain via the vagus nerve. (29)

According to Pharma Foods International’s website, clinical studies have proven the health benefits of their product. (31)

Once ingested, it purportedly binds to GABA receptors in the peripheral nervous system, where the “relaxation response” is elicited 5-30 minutes after ingestion.

Frustratingly, the studies are summarized, but not referenced, on the company website and we could not find them elsewhere online either.

(We’ve contacted the company asking for links to the studies but have not had a response.)

A few brands of GABA supplements that contain PharmaGABA are Swanson, Natural Factors, Thorne, and Designs for Health.

Traditional Herbal Remedies

Naturally relaxing herbs such as hops, valerian, skullcap, lemon balm, chamomile, and passionflower have been used for centuries to induce a state of calm and help users sleep.

It’s no coincidence that these traditional herbal remedies have been found to work on GABA mechanisms in the brain. (32)

You can take these herbs either individually or together.

They are available as pills, capsules, extracts, powders, and teas.

You can also use these herbs’ essential oils to soothe stress and relax.

(However, I’d take a pass on valerian essential oil. It smells awful.)

Two other traditional herbs that support GABA function include Ginkgo biloba, a popular memory supplement, and noni fruit (Morinda citrifolia), a remedy traditionally used to treat depression and anxiety. (33, 34)

Magnolia Bark — Traditional Chinese Remedy

Magnolia bark (Magnolia officinalis) is a versatile herbal remedy.

In traditional Chinese medicine, it is consumed as a tea known as Saiboku-To to treat nervous tension, anxiety, and insomnia. (35)

Now it’s sold for cognitive enhancement, for stress relief, and as a sleep aid.

One of the ways it works is by binding with GABA receptors. (36)

Vitamin B6 — A Needed Cofactor

In the body, the neurotransmitter GABA is synthesized from the excitatory neurotransmitter glutamate and vitamin B6 (pyridoxine), an essential cofactor. (37)

Inadequate levels of B6 contributes to stress in two ways.

First, it can lead to diminished GABA synthesis. (38)

Too little B6 also leads to a buildup of glutamate which in turn can contribute to anxiety, chronic pain disorders, and neurodegenerative diseases. (39, 40)

The recommended RDA (Recommended Dietary Allowance) for vitamin B6 is 1.3 mg/day for most adults. (41)

Picamilon — The “Smart Drug” GABA Supplement

Picamilon is a highly bioavailable version of GABA supplementation.

Developed in the former Soviet Union, it combines GABA with niacin to create a substance that can enter the brain. (42)

In Russia, it’s available as a prescription drug for treating stroke, depression, migraine headaches, and other neurological conditions.

Picamilon is used as a smart drug by college students who use it to boost memory, focus, and mental performance.

Others take it for anxiety, depression, high blood pressure, and migraine relief.

In the US, picamilon was available as a nutritional supplement, but a few years ago, it was pulled from store shelves by the US Food and Drug Administration (FDA).

This was not because picamilon is unsafe, but because it does not meet the FDA’s official definition of a dietary supplement. (43)

So, you won’t find picamilon at your local health food store or typical online vitamin stores, but you can still buy it from online specialty nootropics sites based outside of the US.

We don’t recommend doing this, but if you do, be sure to choose your vendor carefully.

Foods That Contain GABA

To increase GABA, you don’t need to rely solely on supplements.

You can include GABA-rich foods in your diet.

You can get the most stress relief by taking GABA supplements and emphasizing healthy foods that support or contain GABA.

Researchers have found GABA in a surprising number of plant foods.

The top food sources are brown rice germ, sprouted grains, and spinach. (44)

One important group of foods we would add to this list is fermented foods like unpasteurized sauerkraut, kefir, and yogurt.

You’ve already read how probiotic supplements can positively impact your GABA levels, and fermented foods can do the same. (46)

A Word About GABA in Canned Drinks

Soda sales have been going down as energy drink sales have been going through the roof.

Now there is an emerging market of designer relaxation drinks like Just Chill, Zenify, and Marley’s Mellow Mood. 

They contain ingredients known for their calming effects, including GABA, theanine, kava, passionflower, and valerian.

But a Consumer Reports analysis found that these drinks contain only trace amounts of these active ingredients. (47)

Definitely not enough to change your neurotransmitter levels or your mood.

If you are looking for a brain-enhancing drink that will increase GABA, consider brewing your own green tea.

It’s a more affordable and reliable way to reduce stress and improve brain function.

It contains the relaxing compound l-theanine and is lower in caffeine than most caffeinated drinks with only 25 mg per cup.

This is important since caffeine inhibits the release of GABA. (48)

The Best Exercise to Increase GABA

There’s one more way you can increase GABA naturally — with exercise.

Physical exercise is one of the best things you can do to promote happiness, relieve anxiety, and become more resilient to stress.

All kinds of exercise can increase your feel-good neurotransmitters, including GABA.

But yoga, in particular, stands out as a proven GABA booster.

One study found that just a single one-hour session of yoga increased GABA levels by 27%. (49)

Yoga is a popular remedy for stress reduction and now there is at least one explanation for how it works.